Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease

BACKGROUND: Complement proteins and activation products have been found associated with neuropathology in Alzheimer's disease (AD). Recently, a C5a receptor antagonist was shown to suppress neuropathology in two murine models of AD, Tg2576 and 3xTg. Previously, a genetic deficiency of C1q in th...

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Detalhes bibliográficos
Main Authors: Fonseca, Maria I, Chu, Shu-Hui, Berci, Alisia M, Benoit, Marie E, Peters, Douglas G, Kimura, Yuko, Tenner, Andrea J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033336/
https://ncbi.nlm.nih.gov/pubmed/21235806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-4
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