Failed Clearance of Aneuploid Embryonic Neural Progenitor Cells Leads to Excess Aneuploidy in the Atm-Deficient But Not the Trp53-Deficient Adult Cerebral Cortex

Aneuploid neurons populate the normal adult brain, but the cause and the consequence of chromosome abnormalities in the CNS are poorly defined. In the adult cerebral cortex of three genetic mutants, one of which is a mouse model of the human neurodegenerative disease ataxia-telangiectasia (A-T), we...

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Veröffentlicht in:J Neurosci
Hauptverfasser: McConnell, Michael J., Kaushal, Dhruv, Yang, Amy H., Kingsbury, Marcy A., Rehen, Stevens K., Treuner, Kai, Helton, Robert, Annas, Emily G., Chun, Jerold, Barlow, Carrolee
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2004
Schlagworte:
Neurobiology of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729802/
https://ncbi.nlm.nih.gov/pubmed/15371510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2263-04.2004
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