Activation of the IκB Kinase Complex and Nuclear Factor-κB Contributes to Mutant Huntingtin Neurotoxicity

Transcriptional dysregulation by mutant huntingtin (Htt) protein has been implicated in the pathogenesis of Huntington's disease (HD). We find that cultured cells expressing mutant Htt and striatal cells from HD transgenic mice have elevated nuclear factor-κB (NF-κB) activity. Furthermore, NF-κ...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Khoshnan, Ali, Ko, Jan, Watkin, Erin E., Paige, Lisa A., Reinhart, Peter H., Patterson, Paul H.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2004
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729796/
https://ncbi.nlm.nih.gov/pubmed/15371500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2675-04.2004
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