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Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain

Multiple lines of evidence implicate β-amyloid (Aβ) in the pathogenesis of Alzheimer's disease (AD), but the mechanisms whereby Aβ is involved remain unclear. Addition of Aβ to the extracellular space can be neurotoxic. Intraneuronal Aβ42 accumulation is also associated with neurodegeneration....

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Pubblicato in:J Neurosci
Autori principali: Takahashi, Reisuke H., Almeida, Claudia G., Kearney, Patrick F., Yu, Fangmin, Lin, Michael T., Milner, Teresa A., Gouras, Gunnar K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729733/
https://ncbi.nlm.nih.gov/pubmed/15071107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5167-03.2004
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