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β-Amyloid Peptide at Sublethal Concentrations Downregulates Brain-Derived Neurotrophic Factor Functions in Cultured Cortical Neurons

The accumulation of β-amyloid (Aβ) is one of the etiological factors in Alzheimer's disease (AD). It has been assumed that the underlying mechanism involves a critical role of Aβ-induced neurodegeneration. However, low levels of Aβ, such as will accumulate during the course of the disease, may...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Tong, Liqi, Balazs, Robert, Thornton, Phillip L., Cotman, Carl W.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729714/
https://ncbi.nlm.nih.gov/pubmed/15282285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5463-03.2004
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