Sublethal Doses of β-Amyloid Peptide Abrogate DNA-dependent Protein Kinase Activity

Accumulation of DNA damage and deficiency in DNA repair potentially contribute to the progressive neuronal loss in neurodegenerative disorders, including Alzheimer disease (AD). In multicellular eukaryotes, double strand breaks (DSBs), the most lethal form of DNA damage, are mainly repaired by the n...

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Detalhes bibliográficos
Main Authors: Cardinale, Alessio, Racaniello, Mauro, Saladini, Serena, De Chiara, Giovanna, Mollinari, Cristiana, de Stefano, Maria Chiara, Pocchiari, Maurizio, Garaci, Enrico, Merlo, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268421/
https://ncbi.nlm.nih.gov/pubmed/22139836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.276550
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