Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons

Brain-derived neurotrophic factor (BDNF) plays a critical role in nervous system and cardiovascular development and function. Recently, a common single nucleotide polymorphism in the bdnf gene, resulting in a valine to methionine substitution in the prodomain (BDNF(Met)), has been shown to lead to m...

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Detalles Bibliográficos
Publicado en:J Neurosci
Autores principales: Chen, Zhe-Yu, Patel, Paresh D., Sant, Gayatree, Meng, Chui-Xiang, Teng, Kenneth K., Hempstead, Barbara L., Lee, Francis S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2004
Materias:
Cellular/Molecular
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729450/
https://ncbi.nlm.nih.gov/pubmed/15128854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0348-04.2004
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