Traumatic Axonal Injury Induces Proteolytic Cleavage of the Voltage-Gated Sodium Channels Modulated by Tetrodotoxin and Protease Inhibitors

We demonstrated previously that dynamic stretch injury of cultured axons induces structural changes and Ca(2+) influx modulated by tetrodotoxin (TTX)-sensitive voltage-gated sodium channels (NaChs). In the present study, we evaluated potential damage to the NaCh α-subunit, which can cause noninactiv...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Iwata, Akira, Stys, Peter K., Wolf, John A., Chen, Xiao-Han, Taylor, Andrew G., Meaney, David F., Smith, Douglas H.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2004
Assuntos:
Cellular/Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729402/
https://ncbi.nlm.nih.gov/pubmed/15140932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0515-03.2004
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