TGFβ Impairs HNF1α Functional Activity in Epithelial-to-Mesenchymal Transition Interfering With the Recruitment of CBP/p300 Acetyltransferases

The cytokine transforming growth factor β (TGFβ) plays a crucial role in the induction of both epithelial-to-mesenchymal transition (EMT) program and fibro-cirrhotic process in the liver, where it contributes also to organ inflammation following several chronic injuries. All these pathological situa...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Main Authors: Bisceglia, Francesca, Battistelli, Cecilia, Noce, Valeria, Montaldo, Claudia, Zammataro, Agatino, Strippoli, Raffaele, Tripodi, Marco, Amicone, Laura, Marchetti, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6728925/
https://ncbi.nlm.nih.gov/pubmed/31543815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00942
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