Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice

Neurological complications affecting the central nervous system have been reported in adult patients infected by Zika virus (ZIKV) but the underlying mechanisms remain unknown. Here, we report that ZIKV replicates in human and mouse adult brain tissue, targeting mature neurons. ZIKV preferentially t...

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Publicado en:Nat Commun
Main Authors: Figueiredo, Claudia P., Barros-Aragão, Fernanda G. Q., Neris, Rômulo L. S., Frost, Paula S., Soares, Carolina, Souza, Isis N. O., Zeidler, Julianna D., Zamberlan, Daniele C., de Sousa, Virginia L., Souza, Amanda S., Guimarães, André Luis A., Bellio, Maria, Marcondes de Souza, Jorge, Alves-Leon, Soniza V., Neves, Gilda A., Paula-Neto, Heitor A., Castro, Newton G., De Felice, Fernanda G., Assunção-Miranda, Iranaia, Clarke, Julia R., Da Poian, Andrea T., Ferreira, Sergio T.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6728367/
https://ncbi.nlm.nih.gov/pubmed/31488835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11866-7
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