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Roles for DNA polymerase δ in initiating and terminating leading strand DNA replication

Most current evidence indicates that DNA polymerases ε and δ, respectively, perform the bulk of leading and lagging strand replication of the eukaryotic nuclear genome. Given that ribonucleotide and mismatch incorporation rates by these replicases influence somatic and germline patterns of variation...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhou, Zhi-Xiong, Lujan, Scott A., Burkholder, Adam B., Garbacz, Marta A., Kunkel, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6728351/
https://ncbi.nlm.nih.gov/pubmed/31488849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11995-z
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