Transcriptome and Proteome Profiling of Neural Induced Pluripotent Stem Cells from Individuals with Down Syndrome Disclose Dynamic Dysregulations of Key Pathways and Cellular Functions

Down syndrome (DS) or trisomy 21 (T21) is a leading genetic cause of intellectual disability. To gain insights into dynamics of molecular perturbations during neurogenesis in DS, we established a model using induced pluripotent stem cells (iPSC) with transcriptome profiles comparable to that of norm...

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Gepubliceerd in:Mol Neurobiol
Hoofdauteurs: Sobol, Maria, Klar, Joakim, Laan, Loora, Shahsavani, Mansoureh, Schuster, Jens, Annerén, Göran, Konzer, Anne, Mi, Jia, Bergquist, Jonas, Nordlund, Jessica, Hoeber, Jan, Huss, Mikael, Falk, Anna, Dahl, Niklas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer US 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6728280/
https://ncbi.nlm.nih.gov/pubmed/30989628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-019-1585-3
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