DNA methylation changes in Down syndrome derived neural iPSCs uncover co-dysregulation of ZNF and HOX3 families of transcription factors

BACKGROUND: Down syndrome (DS) is characterized by neurodevelopmental abnormalities caused by partial or complete trisomy of human chromosome 21 (T21). Analysis of Down syndrome brain specimens has shown global epigenetic and transcriptional changes but their interplay during early neurogenesis rema...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Clin Epigenetics
Päätekijät: Laan, Loora, Klar, Joakim, Sobol, Maria, Hoeber, Jan, Shahsavani, Mansoureh, Kele, Malin, Fatima, Ambrin, Zakaria, Muhammad, Annerén, Göran, Falk, Anna, Schuster, Jens, Dahl, Niklas
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2020
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6950999/
https://ncbi.nlm.nih.gov/pubmed/31915063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0803-1
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