Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-Palmitoylation

Signal transducer and activator of transcription 3 (STAT3) plays a critical role in regulating cell fate, inflammation and immunity(1,2). Cytokines and growth factors activate STAT3 through kinase-mediated tyrosine phosphorylation and dimerization(3,4). It remains unknown whether other factors could...

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Pubblicato in:Nature
Autori principali: Niu, Jixiao, Sun, Yang, Chen, Baoen, Zheng, Baohui, Jarugumilli, Gopala K., Walker, Sarah R., Hata, Aaron N., Mino-Kenudson, Mari, Frank, David A., Wu, Xu
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6728214/
https://ncbi.nlm.nih.gov/pubmed/31462771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1511-x
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