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Recent Advances in Validating MDM2 as a Cancer Target

The MDM2 oncogene is overexpressed in various human cancers. Its expression correlates with the phenotypes of high-grade, late-stage, and more resistant tumors. The auto-regulatory loop between MDM2 and the tumor suppressor p53 has long been considered the epitome of a rational target for cancer the...

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Bibliographic Details
Published in:Anticancer Agents Med Chem
Main Authors: Rayburn, Elizabeth R., Ezell, Scharri J., Zhang, Ruiwen
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6728151/
https://ncbi.nlm.nih.gov/pubmed/19538162
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