Generation of dual specific bivalent BiTEs (dbBIspecific T-cell engaging antibodies) for cellular immunotherapy

BACKGROUND: Bispecific T-cell engaging antibodies (BiTES), comprising dual anti-CD3 and anti-tumor antigen scFv fragments, are important therapeutic agents for the treatment of cancer. The dual scFv construct for BiTES requires proper protein folding while their small molecular size leads to rapid k...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Kujawski, Maciej, Li, Lin, Bhattacharya, Supriyo, Wong, Patty, Lee, Wen-Hui, Williams, Lindsay, Li, Harry, Chea, Junie, Poku, Kofi, Bowles, Nicole, Vaidehi, Nagarajan, Yazaki, Paul, Shively, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Technical Advance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727398/
https://ncbi.nlm.nih.gov/pubmed/31488104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-6056-8
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