Contribution of Coiled-Coil Assembly to Ca(2+)/Calmodulin-Dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-Associated Phenotypes

BACKGROUND: TRPC6 is a nonselective cation channel, and mutations of this gene are associated with FSGS. These mutations are associated with TRPC6 current amplitude amplification and/or delay of the channel inactivation (gain-of-function phenotype). However, the mechanism of the gain-of-function in...

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Dades bibliogràfiques
Publicat a:J Am Soc Nephrol
Autors principals: Polat, Onur K., Uno, Masatoshi, Maruyama, Terukazu, Tran, Ha Nam, Imamura, Kayo, Wong, Chee Fah, Sakaguchi, Reiko, Ariyoshi, Mariko, Itsuki, Kyohei, Ichikawa, Jun, Morii, Takashi, Shirakawa, Masahiro, Inoue, Ryuji, Asanuma, Katsuhiko, Reiser, Jochen, Tochio, Hidehito, Mori, Yasuo, Mori, Masayuki X.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2019
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727271/
https://ncbi.nlm.nih.gov/pubmed/31266820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018070756
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