Contribution of Coiled-Coil Assembly to Ca(2+)/Calmodulin-Dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-Associated Phenotypes

BACKGROUND: TRPC6 is a nonselective cation channel, and mutations of this gene are associated with FSGS. These mutations are associated with TRPC6 current amplitude amplification and/or delay of the channel inactivation (gain-of-function phenotype). However, the mechanism of the gain-of-function in...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Polat, Onur K., Uno, Masatoshi, Maruyama, Terukazu, Tran, Ha Nam, Imamura, Kayo, Wong, Chee Fah, Sakaguchi, Reiko, Ariyoshi, Mariko, Itsuki, Kyohei, Ichikawa, Jun, Morii, Takashi, Shirakawa, Masahiro, Inoue, Ryuji, Asanuma, Katsuhiko, Reiser, Jochen, Tochio, Hidehito, Mori, Yasuo, Mori, Masayuki X.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2019
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727271/
https://ncbi.nlm.nih.gov/pubmed/31266820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018070756
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