Contribution of Coiled-Coil Assembly to Ca(2+)/Calmodulin-Dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-Associated Phenotypes

BACKGROUND: TRPC6 is a nonselective cation channel, and mutations of this gene are associated with FSGS. These mutations are associated with TRPC6 current amplitude amplification and/or delay of the channel inactivation (gain-of-function phenotype). However, the mechanism of the gain-of-function in...

詳細記述

保存先:
書誌詳細
出版年:J Am Soc Nephrol
主要な著者: Polat, Onur K., Uno, Masatoshi, Maruyama, Terukazu, Tran, Ha Nam, Imamura, Kayo, Wong, Chee Fah, Sakaguchi, Reiko, Ariyoshi, Mariko, Itsuki, Kyohei, Ichikawa, Jun, Morii, Takashi, Shirakawa, Masahiro, Inoue, Ryuji, Asanuma, Katsuhiko, Reiser, Jochen, Tochio, Hidehito, Mori, Yasuo, Mori, Masayuki X.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Nephrology 2019
主題:
Basic Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727271/
https://ncbi.nlm.nih.gov/pubmed/31266820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018070756
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