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PLC-mediated PI(4,5)P(2) hydrolysis regulates activation and inactivation of TRPC6/7 channels
Transient receptor potential classical (or canonical) (TRPC)3, TRPC6, and TRPC7 are a subfamily of TRPC channels activated by diacylglycerol (DAG) produced through the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) by phospholipase C (PLC). PI(4,5)P(2) depletion by a heterologousl...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4001779/ https://ncbi.nlm.nih.gov/pubmed/24470487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201311033 |
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