PLC-mediated PI(4,5)P(2) hydrolysis regulates activation and inactivation of TRPC6/7 channels

Transient receptor potential classical (or canonical) (TRPC)3, TRPC6, and TRPC7 are a subfamily of TRPC channels activated by diacylglycerol (DAG) produced through the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) by phospholipase C (PLC). PI(4,5)P(2) depletion by a heterologousl...

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Bibliografiske detaljer
Main Authors: Itsuki, Kyohei, Imai, Yuko, Hase, Hideharu, Okamura, Yasushi, Inoue, Ryuji, Mori, Masayuki X.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2014
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001779/
https://ncbi.nlm.nih.gov/pubmed/24470487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201311033
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