Performance of GFR Slope as a Surrogate End Point for Kidney Disease Progression in Clinical Trials: A Statistical Simulation

BACKGROUND: Randomized trials of CKD treatments traditionally use clinical events late in CKD progression as end points. This requires costly studies with large sample sizes and long follow-up. Surrogate end points like GFR slope may speed up the evaluation of new therapies by enabling smaller studi...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Greene, Tom, Ying, Jian, Vonesh, Edward F., Tighiouart, Hocine, Levey, Andrew S., Coresh, Josef, Herrick, Jennifer S., Imai, Enyu, Jafar, Tazeen H., Maes, Bart D., Perrone, Ronald D., del Vecchio, Lucia, Wetzels, Jack F.M., Heerspink, Hiddo J.L., Inker, Lesley A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2019
Témata:
Meta-Analysis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727266/
https://ncbi.nlm.nih.gov/pubmed/31292198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019010009
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