GFR Slope as a Surrogate End Point for Kidney Disease Progression in Clinical Trials: A Meta-Analysis of Treatment Effects of Randomized Controlled Trials

BACKGROUND: Surrogate end points are needed to assess whether treatments are effective in the early stages of CKD. GFR decline leads to kidney failure, but regulators have not approved using differences in the change in GFR from the beginning to the end of a randomized, controlled trial as an end po...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Inker, Lesley A., Heerspink, Hiddo J. L., Tighiouart, Hocine, Levey, Andrew S., Coresh, Josef, Gansevoort, Ron T., Simon, Andrew L., Ying, Jian, Beck, Gerald J., Wanner, Christoph, Floege, Jürgen, Li, Philip Kam-Tao, Perkovic, Vlado, Vonesh, Edward F., Greene, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2019
Assuntos:
Meta-Analysis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727261/
https://ncbi.nlm.nih.gov/pubmed/31292197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019010007
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