Performance of GFR Slope as a Surrogate End Point for Kidney Disease Progression in Clinical Trials: A Statistical Simulation

BACKGROUND: Randomized trials of CKD treatments traditionally use clinical events late in CKD progression as end points. This requires costly studies with large sample sizes and long follow-up. Surrogate end points like GFR slope may speed up the evaluation of new therapies by enabling smaller studi...

詳細記述

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書誌詳細
出版年:J Am Soc Nephrol
主要な著者: Greene, Tom, Ying, Jian, Vonesh, Edward F., Tighiouart, Hocine, Levey, Andrew S., Coresh, Josef, Herrick, Jennifer S., Imai, Enyu, Jafar, Tazeen H., Maes, Bart D., Perrone, Ronald D., del Vecchio, Lucia, Wetzels, Jack F.M., Heerspink, Hiddo J.L., Inker, Lesley A.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Nephrology 2019
主題:
Meta-Analysis
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727266/
https://ncbi.nlm.nih.gov/pubmed/31292198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019010009
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