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Reducing myeloperoxidase activity decreases inflammation and increases cellular protection in ischemic stroke

Myeloperoxidase (MPO) is a pro-inflammatory enzyme abundantly secreted by activated myeloid cells after stroke. We show that when MPO activity is either blocked by the specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) in wildtype (WT) mice or congenitally absent (MPO(−/−)), there was decreased...

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Bibliografski detalji
Izdano u:J Cereb Blood Flow Metab
Glavni autori: Kim, Hyeon J, Wei, Ying, Wojtkiewicz, Gregory R, Lee, Ji Y, Moskowitz, Michael A, Chen, John W
Format: Artigo
Jezik:Inglês
Izdano: SAGE Publications 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727136/
https://ncbi.nlm.nih.gov/pubmed/29673284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X18771978
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