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Reducing myeloperoxidase activity decreases inflammation and increases cellular protection in ischemic stroke
Myeloperoxidase (MPO) is a pro-inflammatory enzyme abundantly secreted by activated myeloid cells after stroke. We show that when MPO activity is either blocked by the specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) in wildtype (WT) mice or congenitally absent (MPO(−/−)), there was decreased...
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| Publicado no: | J Cereb Blood Flow Metab |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
SAGE Publications
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6727136/ https://ncbi.nlm.nih.gov/pubmed/29673284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X18771978 |
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