Myeloperoxidase propagates damage and is a potential therapeutic target for subacute stroke

Few effective treatment options exist for stroke beyond the hyperacute period. Radical generation and myeloperoxidase (MPO) have been implicated in stroke. We investigated whether pharmacologic reduction or gene deletion of this highly oxidative enzyme reduces infarct propagation and improves outcom...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Forghani, Reza, Kim, Hyeon Ju, Wojtkiewicz, Gregory R, Bure, Lionel, Wu, Yue, Hayase, Makoto, Wei, Ying, Zheng, Yi, Moskowitz, Michael A, Chen, John W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348390/
https://ncbi.nlm.nih.gov/pubmed/25515211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2014.222
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