Disruption of the menin-MLL interaction triggers menin protein degradation via ubiquitin-proteasome pathway

Menin, a protein encoded by the MEN1 gene, suppresses cancers associated with multiple endocrine neoplasia type 1 (MEN1), but promotes the development of a subset of leukemia induced by mixed lineage leukemia (MLL)-derived fusion proteins (MLL-FPs). The crystal structure of menin indicates that it a...

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Veröffentlicht in:Am J Cancer Res
Hauptverfasser: Wu, Yuan, Doepner, Miriam, Hojnacki, Taylor, Feng, Zijie, Katona, Bryson W, He, Xin, Ma, Jian, Cao, Yan, Busino, Luca, Zhou, Fuxiang, Hua, Xianxin
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2019
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726985/
https://ncbi.nlm.nih.gov/pubmed/31497350
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