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Disruption of the menin-MLL interaction triggers menin protein degradation via ubiquitin-proteasome pathway
Menin, a protein encoded by the MEN1 gene, suppresses cancers associated with multiple endocrine neoplasia type 1 (MEN1), but promotes the development of a subset of leukemia induced by mixed lineage leukemia (MLL)-derived fusion proteins (MLL-FPs). The crystal structure of menin indicates that it a...
Tallennettuna:
| Julkaisussa: | Am J Cancer Res |
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| Päätekijät: | , , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
e-Century Publishing Corporation
2019
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6726985/ https://ncbi.nlm.nih.gov/pubmed/31497350 |
| Tagit: |
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