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Activation of PKA via asymmetric allosteric coupling of structurally conserved cyclic nucleotide binding domains

Cyclic nucleotide-binding (CNB) domains allosterically regulate the activity of proteins with diverse functions, but the mechanisms that enable the cyclic nucleotide-binding signal to regulate distant domains are not well understood. Here we use optical tweezers and molecular dynamics to dissect cha...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Hao, Yuxin, England, Jeneffer P., Bellucci, Luca, Paci, Emanuele, Hodges, H. Courtney, Taylor, Susan S., Maillard, Rodrigo A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726620/
https://ncbi.nlm.nih.gov/pubmed/31484930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11930-2
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