Innate αβ T cells Mediate Anti-tumor Immunity by Orchestrating Immunogenic Macrophage Programming

Unconventional T lymphocyte populations are emerging as important regulators of tumor immunity. Despite this, the role of TCRαβ(+)CD4(–)CD8(–)NK1.1(–) innate αβ T-cells (iαβTs) in pancreatic ductal adenocarcinoma (PDA) has not been explored. We found that iαβTs represent ~10% of T-lymphocytes infilt...

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Publicado no:Cancer Discov
Main Authors: Hundeyin, Mautin, Kurz, Emma, Mishra, Ankita, Kochen Rossi, Juan Andres, Liudahl, Shannon M., Leis, Kenna R., Mehrotra, Harshita, Kim, Mirhee, Torres, Luisana E., Ogunsakin, Adesola, Link, Jason, Sears, Rosalie C., Sivagnanam, Shamilene, Goecks, Jeremy, Islam, KM Sadeq, Dolgalev, Igor, Savadkar, Shivraj, Wang, Wei, Aykut, Berk, Leinwand, Joshua, Diskin, Brian, Adam, Salma, Israr, Muhammad, Gelas, Maeliss, Lish, Justin, Chin, Kathryn, Farooq, Mohammad Saad, Wadowski, Benjamin, Wu, Jingjing, Shah, Suhagi, Adeegbe, Dennis O., Pushalkar, Smruti, Vasudevaraja, Varshini, Saxena, Deepak, Wong, Kwok-Kin, Coussens, Lisa M., Miller, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726581/
https://ncbi.nlm.nih.gov/pubmed/31266770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0161
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