The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression

We found that the cancerous pancreas harbors a markedly more abundant microbiome compared to normal pancreas in both mice and humans, while select bacteria are differentially increased in the tumorous pancreas compared to gut. Ablation of the microbiome protects against pre-invasive and invasive PDA...

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Bibliografiska uppgifter
I publikationen:Cancer Discov
Huvudupphovsmän: Pushalkar, Smruti, Hundeyin, Mautin, Daley, Donnele, Zambirinis, Constantinos P., Kurz, Emma, Mishra, Ankita, Mohan, Navyatha, Aykut, Berk, Usyk, Mykhaylo, Torres, Luisana E., Werba, Gregor, Zhang, Kevin, Guo, Yuqi, Li, Qianhao, Akkad, Neha, Lall, Sarah, Wadowski, Benjamin, Gutierrez, Johana, Rossi, Juan Andres Kochen, Herzog, Jeremy W., Diskin, Brian, Torres-Hernandez, Alejandro, Leinwand, Josh, Wang, Wei, Taunk, Pardeep S., Savadkar, Shivraj, Janal, Malvin, Saxena, Anjana, Li, Xin, Cohen, Deirdre, Sartor, R. Balfour, Saxena, Deepak, Miller, George
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6225783/
https://ncbi.nlm.nih.gov/pubmed/29567829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-1134
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