NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma

The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDA) is characterized by immune tolerance, which enables disease to progress unabated by adaptive immunity. However, the drivers of this tolerogenic program are incompletely defined. In this study, we found that NLRP3 promotes exp...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:J Exp Med
Huvudupphovsmän: Daley, Donnele, Mani, Vishnu R., Mohan, Navyatha, Akkad, Neha, Pandian, Gautam S.D. Balasubramania, Savadkar, Shivraj, Lee, Ki Buom, Torres-Hernandez, Alejandro, Aykut, Berk, Diskin, Brian, Wang, Wei, Farooq, Mohammad S., Mahmud, Arif I., Werba, Gregor, Morales, Eduardo J., Lall, Sarah, Wadowski, Benjamin J., Rubin, Amanda G., Berman, Matthew E., Narayanan, Rajkishen, Hundeyin, Mautin, Miller, George
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2017
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461004/
https://ncbi.nlm.nih.gov/pubmed/28442553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161707
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk