Mechanisms of resistance to EGFR inhibition reveal metabolic vulnerabilities in human GBM

Amplification of the epidermal growth factor receptor gene (EGFR) represents one of the most commonly observed genetic lesions in glioblastoma (GBM), however, therapies targeting this signaling pathway have failed clinically. Here, using human tumors, primary patient-derived xenografts (PDXs), and a...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: McKinney, Andrew, Lindberg, Olle R., Engler, Jane R., Chen, Katharine Y., Kumar, Anupam, Gong, Henry, Lu, Kan V., Simonds, Erin F., Cloughesy, Timothy F., Liau, Linda M., Prados, Michael, Bollen, Andrew W., Berger, Mitchel S., Shieh, Joseph T.C., James, C. David, Nicolaides, Theodore P., Yong, William H., Lai, Albert, Hegi, Monika E., Weiss, William A., Phillips, Joanna J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726545/
https://ncbi.nlm.nih.gov/pubmed/31270152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1330
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