Immune Checkpoint Blockade Enhances Shared Neoantigen-Induced T Cell Immunity Directed against Mutated Calreticulin in Myeloproliferative Neoplasms

Somatic frameshift mutations in the calreticulin (CALR) gene are key drivers of cellular transformation in myeloproliferative neoplasms (MPN). All patients carrying these mutations (CALR+ MPN) share an identical sequence in the C-terminus of the mutated CALR protein (mut-CALR), with the potential fo...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Bozkus, Cansu Cimen, Roudko, Vladimir, Finnigan, John P., Mascarenhas, John, Hoffman, Ronald, Iancu-Rubin, Camelia, Bhardwaj, Nina
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726533/
https://ncbi.nlm.nih.gov/pubmed/31266769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1356
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