PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage

The function of PTEN in the cytoplasm largely depends on its lipid-phosphatase activity by antagonizing the PI3K-Akt oncogenic pathway. However, molecular mechanism(s) underlying the role of PTEN in the nucleus remain largely elusive. Here, we report that DNA double-strand breaks (DSBs) promote PTEN...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Zhang, Jinfang, Lee, Yu-Ru, Dang, Fabin, Gan, Wenjian, Menon, Archita Venugopal, Katon, Jesse M., Hsu, Chih-Hung, Asara, John M., Tibarewal, Priyanka, Leslie, Nicholas R., Shi, Yang, Pandolfi, Pier Paolo, Wei, Wenyi
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726527/
https://ncbi.nlm.nih.gov/pubmed/31217297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0083
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