KRAS activation in gastric adenocarcinoma stimulates epithelial-to-mesenchymal transition to cancer stem-like cells and promotes metastasis

Our previous work showed that in a mouse model of gastric adenocarcinoma (GA) with loss of p53 and Cdh1 that adding oncogenic Kras (a.k.a. Tcon mice) accelerates tumorigenesis and metastasis. Here we sought to examine KRAS activation in epithelial-to-mesenchymal transition (EMT) and generation of ca...

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Udgivet i:Mol Cancer Res
Main Authors: Yoon, Changhwan, Till, Jacob, Cho, Soo-Jeong, Chang, Kevin K., Lin, Jian-xian, Huang, Chang-ming, Ryeom, Sandra, Yoon, Sam S.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726517/
https://ncbi.nlm.nih.gov/pubmed/31217166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0077
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