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Chemotherapy resistance in diffuse type gastric adenocarcinoma is mediated by RhoA activation in cancer stem-like cells
PURPOSE: The Lauren diffuse type of gastric adenocarcinoma (DGA), as opposed to the intestinal type (IGA), often harbor mutations in RHOA but little is known about the role of RhoA in DGA. EXPERIMENTAL DESIGN: We examined RhoA activity and RhoA pathway inhibition in DGA cell lines and in two mouse x...
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| Published in: | Clin Cancer Res |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4823002/ https://ncbi.nlm.nih.gov/pubmed/26482039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1356 |
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