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Chemotherapy resistance in diffuse type gastric adenocarcinoma is mediated by RhoA activation in cancer stem-like cells

PURPOSE: The Lauren diffuse type of gastric adenocarcinoma (DGA), as opposed to the intestinal type (IGA), often harbor mutations in RHOA but little is known about the role of RhoA in DGA. EXPERIMENTAL DESIGN: We examined RhoA activity and RhoA pathway inhibition in DGA cell lines and in two mouse x...

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Bibliografische gegevens
Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Yoon, Changhwan, Cho, Soo-Jeong, Aksoy, Bülent Arman, Park, Do Joong, Schultz, Nikolaus, Ryeom, Sandra W., Yoon, Sam S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823002/
https://ncbi.nlm.nih.gov/pubmed/26482039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1356
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