KMT2C mutations in diffuse type gastric adenocarcinoma promote epithelial-to-mesenchymal transition

PURPOSE: Lauren diffuse type gastric adenocarcinoma (DGA) is genomically stable. We identified lysine (K)-specific methyltransferase 2C (KMT2C) as a frequently mutated gene and examined its role in DGA progression. EXPERIMENTAL DESIGN AND RESULTS: Whole exome sequencing on tumor samples of 27 patien...

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Publié dans:Clin Cancer Res
Auteurs principaux: Cho, Soo-Jeong, Yoon, Changhwan, Lee, Jun Ho, Chang, Kevin K., Lin, Jian-xian, Kim, Young-Ho, Kook, Myeong-Cherl, Aksoy, Bülent Arman, Park, Do Joong, Ashktorab, Hassan, Smoot, Duane T., Schultz, Nikolaus, Yoon, Sam S.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295255/
https://ncbi.nlm.nih.gov/pubmed/30108106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1679
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