Recycling endosomes in mature epithelia restrain tumorigenic signaling

The effects of polarized membrane trafficking in mature epithelial tissue on cell growth and cancer progression have not been fully explored in vivo. A majority of colorectal cancers have reduced and mislocalized Rab11, a small GTPase dedicated to trafficking of recycling endosomes. Patients with lo...

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Veröffentlicht in:Cancer Res
Hauptverfasser: D’Agostino, Luca, Nie, Yingchao, Goswami, Sayantani, Tong, Kevin, Yu, Shiyan, Bandyopadhyay, Sheila, Flores, Juan, Zhang, Xiao, Balasubramanian, Iyshwarya, Joseph, Ivor, Sakamori, Ryotaro, Farrell, Victoria, Li, Qi, Yang, Chung S., Gao, Bin, Ferraris, Ronaldo P., Yehia, Ghassan, Bonder, Edward M., Goldenring, James R., Verzi, Michael P., Zhang, Lanjing, Ip, Y. Tony, Gao, Nan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726494/
https://ncbi.nlm.nih.gov/pubmed/31239271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-4075
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