The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia

Iron acquisition is critical for life. Ferroportin (FPN) exports iron from mature erythrocytes, and deletion of the Fpn gene results in hemolytic anemia and increased fatality in malaria-infected mice. The FPN Q248H mutation (glutamine to histidine at position 248) renders FPN partially resistant to...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Sci Adv
Κύριοι συγγραφείς: Muriuki, John Muthii, Mentzer, Alexander J., Band, Gavin, Gilchrist, James J., Carstensen, Tommy, Lule, Swaib A., Goheen, Morgan M., Joof, Fatou, Kimita, Wandia, Mogire, Reagan, Cutland, Clare L., Diarra, Amidou, Rautanen, Anna, Pomilla, Cristina, Gurdasani, Deepti, Rockett, Kirk, Mturi, Neema, Ndungu, Francis M., Scott, J. Anthony G., Sirima, Sodiomon B., Morovat, Alireza, Prentice, Andrew M., Madhi, Shabir A., Webb, Emily L., Elliott, Alison M., Bejon, Philip, Sandhu, Manjinder S., Hill, Adrian V. S., Kwiatkowski, Dominic P., Williams, Thomas N., Cerami, Carla, Atkinson, Sarah H.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Association for the Advancement of Science 2019
Θέματα:
Research Articles
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726445/
https://ncbi.nlm.nih.gov/pubmed/31517041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw0109
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