The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia

Iron acquisition is critical for life. Ferroportin (FPN) exports iron from mature erythrocytes, and deletion of the Fpn gene results in hemolytic anemia and increased fatality in malaria-infected mice. The FPN Q248H mutation (glutamine to histidine at position 248) renders FPN partially resistant to...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Muriuki, John Muthii, Mentzer, Alexander J., Band, Gavin, Gilchrist, James J., Carstensen, Tommy, Lule, Swaib A., Goheen, Morgan M., Joof, Fatou, Kimita, Wandia, Mogire, Reagan, Cutland, Clare L., Diarra, Amidou, Rautanen, Anna, Pomilla, Cristina, Gurdasani, Deepti, Rockett, Kirk, Mturi, Neema, Ndungu, Francis M., Scott, J. Anthony G., Sirima, Sodiomon B., Morovat, Alireza, Prentice, Andrew M., Madhi, Shabir A., Webb, Emily L., Elliott, Alison M., Bejon, Philip, Sandhu, Manjinder S., Hill, Adrian V. S., Kwiatkowski, Dominic P., Williams, Thomas N., Cerami, Carla, Atkinson, Sarah H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726445/
https://ncbi.nlm.nih.gov/pubmed/31517041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw0109
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