Lobular carcinomas in situ display intra-lesion genetic heterogeneity and clonal evolution in the progression to invasive lobular carcinoma

PURPOSE: Lobular carcinoma in situ (LCIS) is a pre-invasive lesion of the breast. We sought to define its genomic landscape, whether intra-lesion genetic heterogeneity is present in LCIS, and the clonal relatedness between LCIS and invasive breast cancers. EXPERIMENTAL DESIGN: We reanalyzed whole-ex...

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Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Lee, Ju Youn, Schizas, Michail, Geyer, Felipe C., Selenica, Pier, Piscuoglio, Salvatore, Sakr, Rita A., Ng, Charlotte K. Y., Scarpa Carniello, Jose V., Towers, Russell, Giri, Dilip D., de Andrade, Victor P., Papanastasiou, Anastasios D., Viale, Agnes, Harris, Reuben S., Solit, David B., Weigelt, Britta, Reis-Filho, Jorge S., King, Tari A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726436/
https://ncbi.nlm.nih.gov/pubmed/30185420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1103
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