Lobular carcinomas in situ display intra-lesion genetic heterogeneity and clonal evolution in the progression to invasive lobular carcinoma

PURPOSE: Lobular carcinoma in situ (LCIS) is a pre-invasive lesion of the breast. We sought to define its genomic landscape, whether intra-lesion genetic heterogeneity is present in LCIS, and the clonal relatedness between LCIS and invasive breast cancers. EXPERIMENTAL DESIGN: We reanalyzed whole-ex...

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Publicat a:Clin Cancer Res
Autors principals: Lee, Ju Youn, Schizas, Michail, Geyer, Felipe C., Selenica, Pier, Piscuoglio, Salvatore, Sakr, Rita A., Ng, Charlotte K. Y., Scarpa Carniello, Jose V., Towers, Russell, Giri, Dilip D., de Andrade, Victor P., Papanastasiou, Anastasios D., Viale, Agnes, Harris, Reuben S., Solit, David B., Weigelt, Britta, Reis-Filho, Jorge S., King, Tari A.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726436/
https://ncbi.nlm.nih.gov/pubmed/30185420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1103
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