Axonal Transport, Amyloid Precursor Protein, Kinesin-1, and the Processing Apparatus: Revisited

The sequential enzymatic actions of β-APP cleaving enzyme 1 (BACE1), presenilins (PS), and other proteins of the γ-secretase complex liberate β-amyloid (Aβ) peptides from larger integral membrane proteins, termed β-amyloid precursor proteins (APPs). Relatively little is known about the normal functi...

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Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Lazarov, Orly, Morfini, Gerardo A., Lee, Edward B., Farah, Mohamed H., Szodorai, Anita, DeBoer, Scott R., Koliatsos, Vassilis E., Kins, Stefan, Lee, Virginia M.-Y., Wong, Philip C., Price, Donald L., Brady, Scott T., Sisodia, Sangram S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2005
Schlagworte:
Neurobiology of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726084/
https://ncbi.nlm.nih.gov/pubmed/15745965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3089-04.2005
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