A Highly Specific Inhibitor of Matrix Metalloproteinase-9 Rescues Laminin from Proteolysis and Neurons from Apoptosis in Transient Focal Cerebral Ischemia

Neuronal cell death occurs during many neurodegenerative disorders and stroke. The aberrant, excessive activity of matrix metalloproteinases (MMPs), especially MMP-9, contributes directly to neuron apoptosis and brain damage (Rosenberg et al., 1996; Asahi et al., 2001; Gu et al., 2002; Horstmann et...

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Publicado en:J Neurosci
Autores principales: Gu, Zezong, Cui, Jiankun, Brown, Stephen, Fridman, Rafael, Mobashery, Shahriar, Strongin, Alex Y., Lipton, Stuart A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2005
Materias:
Neurobiology of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725288/
https://ncbi.nlm.nih.gov/pubmed/16000631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1563-05.2005
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