Physiological Regulation of the β-Amyloid Precursor Protein Signaling Domain by c-Jun N-Terminal Kinase JNK3 during Neuronal Differentiation

β-Amyloid precursor protein (APP) is a conserved and ubiquitous transmembrane glycoprotein strongly implicated in the pathogenesis of Alzheimer's disease but whose normal biological function is unknown. Analogy to the Notch protein suggests that APP is a cell-surface receptor that signals via s...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Kimberly, W. Taylor, Zheng, Jessica B., Town, Terrence, Flavell, Richard A., Selkoe, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724978/
https://ncbi.nlm.nih.gov/pubmed/15944381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4883-04.2005
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