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Direct RNA nanopore sequencing of full-length coronavirus genomes provides novel insights into structural variants and enables modification analysis

Sequence analyses of RNA virus genomes remain challenging owing to the exceptional genetic plasticity of these viruses. Because of high mutation and recombination rates, genome replication by viral RNA-dependent RNA polymerases leads to populations of closely related viruses, so-called “quasispecies...

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Dades bibliogràfiques
Publicat a:Genome Res
Autors principals: Viehweger, Adrian, Krautwurst, Sebastian, Lamkiewicz, Kevin, Madhugiri, Ramakanth, Ziebuhr, John, Hölzer, Martin, Marz, Manja
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724671/
https://ncbi.nlm.nih.gov/pubmed/31439691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.247064.118
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