STAT3 Mediates the Differential Effects of Oncostatin M and TNFα on RA Synovial Fibroblast and Endothelial Cell Function

Objectives: Oncostatin M (OSM), a pleiotropic cytokine and a member of the gp130/IL-6 cytokine family, has been implicated in the pathogenesis of autoimmune diseases. Here we investigate the mechanisms by which its synergistic interactions with TNFα regulate the cellular bioenergetics and invasive f...

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Publicat a:Front Immunol
Autors principals: Hanlon, Megan M., Rakovich, Tatsiana, Cunningham, Clare C., Ansboro, Sharon, Veale, Douglas J., Fearon, Ursula, McGarry, Trudy
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724663/
https://ncbi.nlm.nih.gov/pubmed/31555281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02056
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