Tofacitinib regulates synovial inflammation in psoriatic arthritis, inhibiting STAT activation and induction of negative feedback inhibitors

BACKGROUND: Psoriatic arthritis (PsA) is a chronic inflammatory disease, characterised by synovitis and destruction of articular cartilage/bone. Janus-kinase and signal transducer and activator of transcription (JAK-STAT) signalling pathway is implicated in the pathogenesis of PsA. OBJECTIVES: To ex...

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Vydáno v:Ann Rheum Dis
Hlavní autoři: Gao, W, McGarry, T, Orr, C, McCormick, J, Veale, D J, Fearon, U
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2016
Témata:
Basic and Translational Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717390/
https://ncbi.nlm.nih.gov/pubmed/26353790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2014-207201
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