Targeting JAK-STAT Signalling Alters PsA Synovial Fibroblast Pro-Inflammatory and Metabolic Function

OBJECTIVES: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis. Janus Kinase inhibitors (JAKi) have emerged as an encouraging class of drugs for the treatment of PsA. Here, we compare the effect of four JAKi on primary PsA synovial fibroblasts (PsAFLS) activation,...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: O’Brien, Aisling, Hanlon, Megan Mary, Marzaioli, Viviana, Wade, Siobhan C., Flynn, Keelin, Fearon, Ursula, Veale, Douglas J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8264423/
https://ncbi.nlm.nih.gov/pubmed/34248953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.672461
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