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Ligand-Free Estrogen Receptor α (ESR1) as Master Regulator for the Expression of CYP3A4 and Other Cytochrome P450 Enzymes in the Human Liver

Cytochrome P450 3A4 isoform (CYP3A4) transcription is controlled by hepatic transcription factors (TFs), but how TFs dynamically interact remains uncertain. We hypothesize that several TFs form a regulatory network with nonlinear, dynamic, and hierarchical interactions. To resolve complex interactio...

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Publicat a:Mol Pharmacol
Autors principals: Wang, Danxin, Lu, Rong, Rempala, Grzegorz, Sadee, Wolfgang
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724575/
https://ncbi.nlm.nih.gov/pubmed/31399483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.116897
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